Disruption of mesodermal enhancers forIgf2in the minute mutant
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چکیده
منابع مشابه
Disruption of mesodermal enhancers for Igf2 in the minute mutant.
The radiation-induced mutation minute (Mnt) in the mouse leads to intrauterine growth retardation with paternal transmission and has been linked to the distal chromosome 7 cluster of imprinted genes. We show that the mutation is an inversion, whose breakpoint distal to H19 disrupts and thus identifies an enhancer for Igf2 expression in skeletal muscle and tongue, and separates the gene from oth...
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ژورنال
عنوان ژورنال: Development
سال: 2002
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.129.7.1657